Tag Archive for: DHT Blocker

Ask an Expert: Can I Combine Hair Growth Treatments

Combining hair loss treatments with Happy Head can get you the best hair growth results. Try combining your hair loss solutions today.

If you’ve been dealing with hair loss, you may have gone down a research rabbit hole to find treatment options. And, if you’re confused by all of the choices out there, you’re not alone. There are so many! Do you have to choose just one, or can you mix and match different hair growth treatments? Are two or three formulas more effective than one? Are side effects more likely? Since so many customers were asking the same questions, we asked our expert, Dr. Ben Behnam, renowned dermatologist and co-founder of Happy Head hair growth treatments, his opinion. Here’s what he tells patients when they ask, “Can I combine hair growth treatments?”

Your Hair Growth Treatment Options: Oral and Topical

Before we answer frequently asked questions about combining medications, let’s talk about the options out there. First, it’s no secret that there plenty of over-the-counter (OTC) hair loss foams, creams, and supplements are out there. Are they just as good as prescription medications? While many OTC hair loss products include tested and proven ingredients, prescription medications are available in higher doses. For example, Minoxidil is available OTC in 2 and 5 percent liquids and foams. You’ll need a prescription, though, to get higher eight or ten percent topical dosages, 

Then, there’s the oral versus topical debate. Which to use often comes down to personal preference. Topical medications have been proven to be equally as effective as oral medications when used at recommended dosages. 

Since topicals aren’t ingested, systemic side effects aren’t typically an issue. If irritation becomes an issue, cortisone or switching to a liposomal formula should solve the problem. Topicals with a liposomal base release medication into the hair follicles gradually, minimizing potential side effects. People concerned about sexual side effects associated with Finasteride, Dutasteride, and other DHT blockers may prefer topicals. 

People who don’t want to apply liquids or creams a couple of times a day may prefer oral pills. Orals are an easy-to-take, no-mess option. Since they are ingested, however, they can cause systemic side effects. 

Benefits of Combining Topical and Oral Medications for Hair Growth

Let’s circle back to where we started. Can you combine topical and oral medications? The answer is, “yes.” 

Dr. Ben likes to call this technique “sandwiching.” Sandwiching by mixing topical and oral hair loss medications helps attack hair loss from multiple angles. Here’s how it works:

Start With Minoxidil

Minoxidil is a vasodilator. That’s a fancy way to say that it widens your blood vessels, increasing oxygen, nutrients, and growth factors. Topical Minoxidil is absorbed into your skin and penetrates the epidermis to reach the hair follicles. Ingested oral Minoxidil works similarly to topical but can affect other blood vessels in your body, too, since it’s systemic. Both topical and oral Minoxidil affect your hair growth cycle. Minoxidil shortens the resting phase when hair stops growing, falls out, and kicks more hair follicles into the growth phase. The result is less hair loss and longer hair growth. 

So, for the sake of this article, let’s say that you read that 61 to 100 percent of patients with androgenetic alopecia (male and female pattern hair loss) who took 0.25 to 0.5 milligrams of oral Minoxidil saw significant improvement. (01) And you decide to give oral Minoxidil a try. What else can you use to treat your hair loss?

Add a DHT Blocker

DHT is the villain that causes androgenetic alopecia by attaching to your hair follicle’s receptors and signaling them to shrink. When that happens, the follicles produce thinner and shorter hair strands. Over time, the weak follicles may stop producing hair altogether. Enter DHT blockers. 

DHT blockers are medications that prevent testosterone from converting to a hormone called Dihydrotestosterone (DHT for short). The most well-known DHT blockers are Finasteride and Dutasteride. Finasteride selectively inhibits type II 5-alpha-reductase enzyme. Targeting this enzyme can help slow down hair loss. Dutasteride inhibits both type 1 and type II of the 5-alpha-reductase enzyme. Because it’s more broad spectrum, it can be more effective at reducing DHT levels in some people, especially those who do not get the desired response from Finasteride. 

Finasteride and Dutasteride are both available orally and topically. Since you’ve already decided to take oral Minoxidil and may not want to take too many systemic medications simultaneously, you can choose to use topical Finsteride or Dutasteride simultaneously.

Note: Looking to get an extra boost out of your DHT blocker? As long as your dermatologist is on board, you can use the same oral and topical DHT blocker, including Finasteride and Dutsteride, simultaneously.

Spironolactone is Another Option for Women

Spironolactone is another type of DHT blocker. It stops the effects of the hormone aldotestosterone that is produced in the adrenal glands. It also blocks DHT, which makes it a popular androgenetic alopecia treatment. Oral Spironolactone is usually only prescribed to women since it can cause breast enlargement. Topical is safe and effective for both men and women. Research indicates that Spironolactone’s efficacy improves when combined with Minoxidil. (02) So, if you’re looking for a treatment to pair up with Minoxidil, Sprionlactone may be a good option.   

Creating a Hair Growth Treatment That Works for You

There isn’t one surefire treatment that works across the board for everyone. Hair loss treatments can be combined in many different ways, and it may take some experimenting to see which combo works best for you. Here are some tips that will help you throughout your hair regrowth journey:

  • Start with a personalized treatment plan. A board-certified dermatologist can evaluate your hair loss and recommend the right medications for you. 
  • Track your progress by taking photos around the same time each month. Your regimen can be adjusted as needed.
  • Manage your stress. Hair is sensitive to your overall well-being. Both short-term and chronic stress can affect your tresses. Go for a walk, listen to your favorite song, get a massage, talk to a therapist… do whatever it takes to keep your head in the right place. 
  • Eat well. Your hair gets its nutrients from your body. The better you feed your body, the healthier your hair will be. 
  • Take care of your hair. Use gentle shampoo and conditioner, avoid heat styling, and get regular trims. 

Let’s recap. Not only can hair growth treatments be combined, it’s often recommended. Since the most effective hair loss treatments are only available by prescription, you’ll need to consult with a dermatologist who specializes in hair loss. Both oral and topical medications are equally as effective. Depending upon your medical history and personal preferences, you may have some flexibility with the type of hair loss medication you choose. Common combinations are Minoxidil with some type of DHT blocker. Oral and topical DHT blockers can often be used at the same time as well. 

If you’re looking for help with your treatment plan, look no further. Happy Head is here to help. Our hair growth specialists, licensed dermatologists located in every state, are available to review your case and make recommendations. You can get customized formulas delivered directly to your front door. Have any questions? Get in touch. We’re here to support you on your hair growth journey. 

Resources:

(01) https://link.springer.com/article/10.1007/s13659-020-00267-9 

(02) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010138/

 

Now Available! Groundbreaking Topical Liposomal Finasteride & Minoxidil Formula

If you’ve used prescription topical hair loss medications in the past, you know they pack a punch. The doses are higher than what’s available over the counter, making them that much more effective. But, there’s a catch. Some people find the liquid formula a little tricky to use. Foams stick to hair strands but don’t necessarily make their way to the scalp, which is where the medicine needs to go. And until now, Happy Head’s prescription topicals were only available in liquid formulas applied with a dropper. Effective? Yes. Drip-free? Not exactly. That’s why we’re excited to introduce our groundbreaking topical liposomal Finasteride and Minoxidil formula. 

What’s In It?

Happy Head’s newest formula contains .3 percent Finasteride and eight percent Minoxidil in a liposomal base. The creamy, soothing base penetrates the scalp yet keeps the active ingredients in the top layer of the epidermis. This offers two benefits. First, it allows the medication to reach hair follicles. Secondly, it prevents the medication from moving into the bloodstream and reduces the chances of potential side effects. (01)

How it Works

Happy Head’s topical liposomal Finasteride & Minoxidil formula is for men and women with androgenic alopecia, known outside the medical field as male and female pattern hair loss. Androgenic alopecia occurs when naturally occurring testosterone converts to dihydrotestosterone (DHT) and builds up in the scalp. DHT kicks the hair growth cycle into a resting state, where hair stops growing and eventually falls out. When this happens, it’s a game of beat-the-clock to keep the shrinking hair follicles viable so new hair can grow. Liposomal Finasteride and Minoxidil formula targets the scalp directly, blocking DHT, and allowing for thicker, healthier hair. 

Easy, Mess-free Application

Use liposomal Finasteride and Minoxidil as you would apply a hair cream. The formula comes in an airless pump bottle. The simple pump design measures out just the right amount. Pump, apply, and rub it in. Easy peasy. The formula is thick enough so it stays in place. No dripping or running down your face. 

Is Topical Liposomal Hair Loss Treatment for You?

Pills, liquids, creams… when it comes to treatment for your hair loss, you have options. A lot of them. So, how do you decide if our new liposomal treatment is right for you? Here’s a quick rundown:

Oral Hair Loss Medications 

Pros: Both Minoxidil and Finasteride are available in pill forms. They’re easy to take and usually only require low dosages once daily to treat hair loss. 

Cons: Minoxidil increases blood flow to your scalp, while Finasteride is a DHT blocker. Dermatologists typically prescribe both to patients with male or female pattern baldness. That means taking two separate pills. Pills are also absorbed systemically into the bloodstream which means that there’s a higher potential for side effects than topical hair loss medications.

Foams

Pros: Available over-the-counter

Cons: Minoxidil foam available without a prescription does not contain Finasteride and is only available in two and five-percent formulas. More difficult to apply than people realize. Just because the foam is on your hair, doesn’t mean it’s reaching your scalp. 

Liquids

Pros: Easily reaches the scalp and can be customized to include desired percentages of each medication.

Cons: May be difficult to apply since liquids are applied with a dropper and can be runny.

Liposomal Formula

Pros: Creamy formula is easy to apply. It works directly on the scalp and has been found to be effective. (02) To date, no other company has made this particular formula available. 

Cons: More expensive than the other options.

Seeing Results

We’ve known for a while now that topical Finasteride is as effective as oral and is less likely to cause undesirable side effects such as decreased libido and erectile dysfunction. (03) Does the cream formula work as well as the liquid formula, though? Initial studies are promising. When the liposomal formula was tested on a small sample of 30 men and 30 women with androgenic alopecia, the results were favorable, especially among women. Hair count significantly increased for women after six months of treatment. Both groups had a significant increase in anagen hair (new hair in the growth phase) and a decrease in telogen hair (resting state when hair falls out) within one to three months. (04)

Regrow Your Hair in a Year

Patients usually start to see new hair growth in three to six months. Growing hair is a process, though. It can take up to a year to see the full results. After all, according to the Trichological Society, your hair grows about .5 to 1.7 centimeters per month. (05) Not seeing much progress? Your hair is probably growing more than you realize. Taking photos on the same date each month and comparing them over time will give you a more realistic idea of the changes your hair is undergoing. 

Have questions? Ready to place an order? We’ve got you covered. 

First, it’s time for an online consultation. Contact us, and let us know you’re interested in trying our new liposomal formula. One of our board-certified dermatologists will review your medical history and ensure that topical liposomal Finasteride and Minoxidil do the trick for your hair loss. If not, we’ll make other recommendations based on your hair’s condition and needs. 

 

Now, get this. Renowned dermatologist and Happy Head Co-founder Dr. Ben Behnam is available to answer your questions about hair loss or medications available to regrow your hair. The Q&A session is completely free. Use this link to sign up for Dr. Ben’s Ask Me Anything Series that’s coming up in August. To get an idea of what types of questions people ask and how the sessions work, check out our previous episodes on YouTube. What foods will make your hair healthier and shinier? Are certain shampoos better than others? Tune in and get your questions answered. 

 

Resources:

(01) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070339/

(02) https://pubmed.ncbi.nlm.nih.gov/30371981/

(03) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9297965/

(04) https://pubmed.ncbi.nlm.nih.gov/30371981/

(05) https://www.hairscientists.org/hair-and-scalp-conditions/nutrition-and-hair-health

 

 

Your Comprehensive Guide to Oral Dutasteride

Happy Head's dermatologists formulate prescription-grade hair loss treatments with Dutasteride as an active ingredient, made to block hair loss. Learn more about this active ingredient and how it tackles hair loss and prevents future loss while promoting hair growth.

If you’re experiencing male or female pattern baldness, your dermatologist probably recommended a Dihydrotestosterone or DHT blocker. There are a few different types that you may have heard about. Finasteride was the first DHT blocker on the market and the oral version is FDA approved for male pattern hair loss. Dutasteride is a newer medication that’s often used off-label to treat hair loss. If you’re unfamiliar with Dutasteride as a primary ingredient in hair loss treatments then you’re in the right place. We’re going to share everything you need to know about oral Dutasteride in this comprehensive guide and how it can help you achieve successful hair growth. 

Dutasteride is a DHT Blocker

Let’s start with the basics. Both men and women have an enzyme called 5-alpha reductase in their liver and skin. It can also be found in men’s prostates. The enzyme is responsible for converting Testosterone produced into dihydrotestosterone (DHT). Healthy levels of DHT are needed to support sexual development in both men and women. When a person’s DHT level gets too high during adulthood, however, it can cause prostate enlargement in men and hair loss in both men and women. High levels of DHT shrink the hair follicles and shorten the hair growth cycle resulting in hair loss.   

Dutasteride is Designed to Prevent Hair Loss 

DHT blockers like Dutasteride prevent Testosterone from converting into DHT in th

e first place. When production is inhibited, the amount of DHT that can attach to your hair follicles is significantly reduced, limiting the effects on your scalp. 

Dutasteride is a Newer DHT Blocker

Finasteride was the first DHT blocker on the market in 1992. Dutasteride was developed a few years later and patented in 1996. The medication was marketed to treat benign prostatic hyperplasia, another name for enlarged prostates, under the brand name Avodart. In 2015, Dutasteride’s patent expired, making the medication more widely available. Although Dutasteride is not FDA approved for treatment of male or female pattern hair loss and is used off-label in the United States, it has been approved in South Korea since 2009 and Japan since 2015. At Happy Head, every formula we create is thoroughly tested and found to have effective results by our board-certified dermatologists. 

Finasteride and Dutasteride Both Treat Androgenetic Alopecia, but Work Differently

Like Finasteride, Dutasteride inhibits 5a-reductase (5AR). The difference is the number and types of enzymes inhibited. Finasteride selectively inhibits the Type 2 isoenzyme, and Dutastride inhibits both Type 1 and 2. A research study published in the National Library of Medicine on 576 men confirmed that Dutasteride is an effective option for men who don’t respond well to Finasteride. So if you’ve tried Finasteride before without success, just let your Happy Head dermatologist know and they’ll find an effective solution for you or craft one from prescription-grade ingredients just for you. 

Is Dutasteride Stronger 

Than Finasteride?

According to research findings, Dutasteride is a stronger ingredient. In one study on men with Androgenetic Alopecia (male pattern baldness), Dutasteride improved hair growth by over twelve percent after 24 weeks, compared to just seven and a half percent in the group that took Finasteride. However, anecdotally, some dermatologists find that while some patients respond better to Dutasteride, other patients achieve better results with Finasteride. It’s difficult to predict which medication will work better without trying each. 

Dutasteride Has Long-Lasting Effects

Dutasteride remains in your system for a long time after the medication is stopped. It can be detected for up to four to six months after your last dose. In comparison, Finasteride only lasts in your system for five to eight hours. 

Why Not Try Dutasteride First?

When prescribing medications for genetic and other types of hair loss, dermatologists often start with lower strengths and dosages and bump up to higher ones as needed. The system gives you the most effective formulas at the lowest possible dosages to help avoid side effects. After all, Finasteride, which is usually used as a first-line treatment, effectively treats many patients experiencing male and female pattern baldness. Some people never need another DHT blocker. There are times, however, when Finasteride doesn’t do the trick. In those cases, Dutasteride is often prescribed next. 

Are Side Effects Common with Dutasteride?

DHT blockers can cause sexual side effects, such as decreased libido and erectile dysfunction, so some people, especially men, may be hesitant to try them. The truth is that side effects due to Dutasteride are not typical, and most people do not experience them.  According to a study from the National Library of Medicine, eighty-five percent of men who use DHT blockers don’t experience any side effects. Side effects usually dissipate over time after the medication is discontinued.  

What Conditions Does Oral Dutasteride Treat

Dutasteride is most often prescribed to treat male and female pattern hair loss, also known as Androgenetic Alopecia. The condition is genetic and occurs when an overproduction of DHT attacks the hair follicles. Dutasteride stops the flow of DHT to prevent further hair loss and allow new hair to grow. Oral Dutasteride is also prescribed for conditions such as frontal fibrosing alopecia and as appropriate for other forms of alopecia. 

How Long Will It Take to See Results?

Oral Dutasteride may start working immediately, but it will take approximately six months to a year to see a noticeable difference. 

Oral Hair Growth treatments formulated by dermatologists and delivered to your door using Dutasteride, Finasteride, Minoxidil, and more.

Can Oral Dutasteride Be Combined With Minoxidil and Other Hair Loss Treatments?

Not only can Dutasteride be combined with Minoxidil, but it is also recommended. The two medications work differently and together can maximize your hair growth. Here’s how. When people experience androgenetic alopecia, the hair follicles shrink, resulting in shorter and thinner hair. Over time, the hair follicles can completely close, so that hair will no longer grow. Dutasteride blocks DHT from shrinking the follicles, and Minoxidil enlarges the hair follicles, allowing thicker, healthier hair to emerge.  

How to Get Oral Dutasteride

Oral Dutasteride is only available by prescription and should be taken under the supervision of a licensed dermatologist. Be sure to follow-up as recommended by your doctor. As with any medication, Dutasteride should be monitored regularly. 

If you have been diagnosed with male or female pattern baldness and are interested in learning more about Dutasteride, Happy Head can help. Not diagnosed for hair loss but feel like you’re losing hair? You can get a FREE consultation with our board-certified dermatologists and get prescribed the treatment you need online by taking our quick questionnaire here and telling us about your hair. We have licensed dermatologists available in every state to answer your questions and determine whether Dutasteride is right for you. We also help make Dutasteride affordable, whether or not you have insurance. Use code GOHAIR for 50 percent off of your first order. 

Resources:

(01) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388756/

(02) Khandpur, S., & Suman, M. (2014). Dutasteride improves male pattern hair loss in a randomized study in identical twins. Indian journal of dermatology, 59(6), 630-633. doi: 10.4103/0019-5154.143571

(03) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023004/#:~:text=Sexual%20adverse%20effects%2C%20such%20as,the%20symptoms%20improve%20over%20time.

 

How to Avoid Side Effects from Finasteride

If you’ve seen television ads for any medication, you know that almost all of them have potential side effects.  By the time the announcer gets to the end of the (sometimes very long) list, you’re probably wondering why doctors even prescribe the medication in the first place.  But, of course, some medications have more side effects than others.  And, some medications get a bad rap just because one or two out of thousands had unusual reactions.  

Fast forward to Finasteride.  Finasteride, also known as Propecia or Proscar, is often prescribed to treat hair loss due to various conditions.  Finasteride was originally marketed to treat men with enlarged prostates.  During drug trials, doctors noticed that men who took Finasteride as a prostate treatment experienced hair growth.  Finasteride was then FDA-approved to treat hair loss too.  In this case, the side effect was a good one.  However, some male Finasteride users have reported some undesirable sexual side effects.  Should you be concerned?  Not really.  The side effects aren’t typical.  Plus, there are ways to avoid the side effects if that’s a concern.  We’re here to share why you shouldn’t worry if your doctor has prescribed Finasteride to treat your hair loss.         

 

Why is Finasteride Prescribed for Hair Loss?

Finasteride is what’s called a DHT blocker.  DHT is an acronym for dihydrotestosterone, which is an androgen, a male sex hormone. When men and women experience androgenetic alopecia, an enzyme called 5-alpha-reductase converts testosterone to DHT.  When this happens, DHT can bind to the receptors on your hair follicles, shrinking the follicles during a process called miniaturization.  Over time,  the anagen phase of the hair growth cycle is reduced.  The result is hair that is shorter and thinner.  Eventually, new hairs become so small that they can’t penetrate the hair follicle.  As a DHT blocker, Finasteride prevents this process from happening, so you maintain your existing hair and continue to grow healthy new hair.    

What Hair Loss Conditions Does Finasteride Treat?

Oral Finasteride is FDA approved to treat androgenetic alopecia, male and female pattern hair loss.  Male and female pattern hair loss is the most prevalent type of alopecia worldwide.  There isn’t a way to predict who will experience pattern hair loss.  The condition is genetic and can be inherited from either the maternal or paternal sides of the family.  There isn’t a specific test to diagnose androgenetic alopecia.  Dermatologists and hair specialists can make the diagnosis by evaluating a patient’s hair loss pattern. 

Finasteride is also used to treat other types of alopecia, including alopecia areata and lichen planopilaris, which are caused by autoimmune conditions.  However, the prescription is considered off label when prescribed to treat hair loss other than androgenetic alopecia.   

Is Finasteride Effective in Preventing Hair Loss and Stimulating Growth

If you’re wondering whether Finasteride is worth the risk of whatever side effects could occur, that’s a valid question.  Although deciding whether to use Finasteride is highly personal, research indicates that Finasteride is highly effective in promoting growth and preventing further hair loss.  Over 80 percent of men who use Finasteride see improvement, and over 65 percent see new hair growth.  Not only that, the results are long-term.  A study of 1879 men indicates that hair count present after one year was maintained during the second year of treatment.

What are Finasteride’s Side Effects?

Side effects caused by oral Finasteride are usually mild and disappear after you stop taking the medicine.  Here are a few signs to watch:

  • Anxiety 
  • Depression
  • Dizziness
  • Weakness
  • Headache
  • Inability to urinate
  • Testicular pain
  • Runny nose
  • Rash, itching, swelling of the face, lips, or tongue, or other signs of an allergic reaction
  • Swelling of your hands or feet

Although these side effects aren’t exactly desirable, they aren’t most mens’ biggest fear.  Most are more concerned about potential sexual side effects such as:

  • Decreased libido
  • Erectile dysfunction
  • Decreased semen volume
  • Breast enlargement & tenderness
  • Premature ejaculation

The good news is that these side effects aren’t common.  Some men who do experience the sexual side effects find that their symptoms disappear over time as their bodies acclimate to the medication.  If not, discontinuing the use of Finasteride usually resolves the issue.

How Common are Side Effects from Finasteride?

As mentioned previously, side effects from Finasteride aren’t common.  The main reason is that the dosage typically prescribed to treat alopecia is usually very low, much lower than the dosage prescribed for prostate treatment.  As a matter of fact, only 3.8 percent of men who took Finasteride experienced side effects during the drug’s clinical trials.  That’s compared to 2.1 percent of men who took a placebo.  

Want to Avoid Finasteride Side Effects?  Use Topical Finasteride Instead

If you’re still a little worried about using Finasteride, even though the risk of side effects is low, there’s a simple solution. Use topical Finasteride instead of oral Finasteride.  The topical solution has been proven to be just as effective in treating male and female pattern baldness without the same risk of side effects.  Whereas oral Finasteride is metabolized in your stomach, topical Finasteride is not systemic.  Even better, topical Finasteride has less impact on serum DHT concentrations.  Think of it as a highly effective spot treatment for your hair.     

Research also indicates that combining Minoxidil with Finasteride yields even better results than using either medication alone.  Adverse reactions among patients were rare, indicating that the combined medication is not only a good choice, but a preferable one.  

Are You a Good Candidate for Finasteride?

Finasteride is often prescribed to both men and women to treat androgenetic alopecia.  The medication is generally safe for most people.  There are some exceptions though.  Finasteride is not recommended if you have kidney problems, prostate cancer, liver disease, or any other liver-related issues.  The medication is also not recommended to women who are pregnant, trying to get pregnant, or are breastfeeding.

What Should You Do if you Experience sexual or Other Side Effects from Finasteride?

If you think Finasteride is causing side effects, stop taking the medication and contact your dermatologist.  The side effects usually go away after the medication is out of your system.  However, you’ll want to work with your dermatologist to identify a substitute.  

When considering a new medication, it’s important to do your research and feel confident about your choice.  Finasteride is no exception.  If you have questions and are looking for answers, we’re here to help.  Our board-certified dermatologists and hair specialists look forward to giving you the information you need, when you need it, to get the healthiest, most effective hair loss treatment.  

 

Resources:

(01) https://pubmed.ncbi.nlm.nih.gov/9951956/

(02) https://pubmed.ncbi.nlm.nih.gov/9951956/

(03) https://pubmed.ncbi.nlm.nih.gov/34634163/#:~:text=Conclusion%3A%20Topical%20finasteride%20significantly%20improves,impact%20on%20serum%20DHT%20concentrations.

(04) https://pubmed.ncbi.nlm.nih.gov/32166351/

 

DHT Blockers: Fight Hair Loss with These Powerful Weapons

Men are willing to do just about anything besides see a doctor.   Given a choice, 72 percent of men would rather clean the bathroom, mow the lawn, or do any other household chores. A lot of men aren’t even getting their yearly check-ups. (01)   So when it comes to hair loss, not many guys are rush to the dermatologist for a diagnosis and medication.  But they should.  

The most powerful hair loss weapons against male pattern baldness are only available by prescription.  Sure, there’s an endless number of products sold over-the-counter claiming that they work, but the reality is that they aren’t powerful enough to get the job done.  This is true for women who have female pattern baldness too.   

If your hair is thinning or balding, a DHT blocker may be just what the doctor ordered.  Read on to learn more about what DHT is, why DHT is causing your hair loss, and why DHT blockers may be the solution to your hair loss issues.  

What is DHT?

Dihydrotestosterone (DHT) is a sex hormone, known as an androgen.   Androgens are typically produced in males’ testicles and women’s ovaries.  The adrenal glands also produce androgens.  DHT is a little different than other androgens, because it is converted from testosterone.  Men naturally have more testosterone in their bodies than women, however, an enzyme called 5-alpha reductase (5-AR) converts about ten percent of testosterone in all adults to DHT.  

How Does DHT Cause Hair Loss?

When too much testosterone converts into DHT, the excess amounts of DHT interfere with your hair’s growth cycle.  The hair follicles miniaturize, make existing hair fall out, and prevent new hair from breaking through.    

Will a Blood Test Tell Me If I’m Producing Too Much DHT?

It seems logical that DHT levels can be monitored since testosterone levels can be checked.  That’s not the case, though.  DHT levels may fall within the normal range on a blood test but still be elevated enough to cause male or female pattern baldness.  This is especially true if your body is sensitive to DHT.  When testosterone levels increase, DHT has the potential to be an even bigger problem.  

Can I Prevent Androgenetic Alopecia?

Unfortunately, there isn’t a way to predict whether or not you’re going to lose your hair.  Androgenetic alopecia, male and female pattern baldness, is genetic.  If a family member on either your maternal or paternal side has gone bald, there’s a chance that you could too. The only catch is that you don’t have a way of knowing whose or which genes you inherited.  

Men on testosterone replacement therapy or get testosterone injections often ask if the medication will contribute to their hair loss.  Depending on the patient’s sensitivity, the supplemental testosterone could cause an increase in DHT leading to increased hair loss.  

Is Overproduction of DHT Just a Guy Problem?

When people think of androgenetic alopecia, men typically come to mind.  Bruce Willis, The Rock, Matthew McConaughey, Jeff Bezos are all prime examples.  You don’t see too many bald or balding female celebrities.  The reality is that a significant number of women are affected although the number isn’t as high as it is for men.  One research study found that out of 954 patients diagnosed with pattern baldness, 23.9 percent were women. (02)  Women typically have a lower level of testosterone; however even when lower levels of testosterone convert to DHT, hair loss can occur.  

What Can You Do to Reduce the DHT Levels in your Body?

The most effective way to reduce your DHT level is to use a DHT blocker.  If you’ve been dealing with hair loss issues for a while, you’re probably well aware of the overwhelming number of over-the-counter (OTC) hair loss options.  It’s not unusual for patients to spend a lot of time and money with these products before giving up and turning to their dermatologists for prescription options. 

Prescription DHT blocking medications reduce the amount of 5a-reductase enzyme, which converts testosterone into DHT in your body.  Here are the DHT blockers most commonly prescribed by dermatologists and hair specialists:

Oral & Topical Finasteride 

Finasteride is one of the most well-known DHT blockers.  The medication was FDA approved in 1992 under the name Proscar to treat enlarged prostates and five years later under the name Propecia to treat androgenetic alopecia.  Although both men and women can use Finasteride, it is not recommended for use in women who are or could become pregnant.  

Oral Finasteride is highly effective as a hair loss treatment.  One research study found that 80 percent of participants who took Finasteride saw an increase in hair growth. (03)  However, some people who take oral Finasteride report undesirable sexual side effects, including decreased libido.  A good solution is using topical Finasteride rather than oral.  Topical Finasteride has been proven to be as effective as oral without the side effects in many studies. (04)  

Topical Finasteride Combined With Minoxidil

Minoxidil is not a DHT blocker, but it has an important role in hair growth for people with male and female pattern baldness.  Minoxidil is what’s called a vasodilator.  It enlarges the blood vessels so more oxygen reaches the scalp.  As a result, it makes the hair follicles bigger so new hair can emerge.  Minodixil and Finasteride are a dynamic duo when used together to fight hair loss.  The Finasteride prevents the testosterone from converting into DHT while the Minoxidil ensures that your scalp is conducive to new hair growth.  A research study conducted in 2020 found that the combination of Finasteride and Monoxidil was safe and more effective than monotherapy. (05)

Dutasteride

Dutasteride, also known as Avodart, is another DHT blocker originally developed to treat enlarged prostates.  It is also a 5-alpha reductase inhibitor.  Although Finasteride and Dutasteride work similarly, the medications have some differences.   Whereas Finasteride is FDA-approved to use for hair loss, Dutasteride can only be used off-label.  It has not yet been FDA-approved.  Finasteride is usually highly effective in treating androgenetic alopecia and is typically used as a first-line medication.  In cases where patients need an extra boost, Dutasteride can be helpful.  Research has shown that men who used Dutasteride for 24 weeks had thicker hair than men who used Finasteride. (06) 

Spironolactone

Spironolactone is FDA approved to treat high blood pressure, heart failure, and fluid retention due to kidney and liver diseases.  It is not FDA-approved to use for hair loss and is used off-label for women.  Spironolactone typically isn’t prescribed to men because it can cause feminizing side effects.  Like Finasteride and Dutasteride, Spironolactone slows down androgen production.  The medication has been found to be both safe and effective. (07)

How Do DHT Blockers Work?

Now that you have a better idea of what DHT blockers are available, the next question that needs to be answered is how do they work?  The mechanics behind the prescription medications approved or used as DHT blockers are similar.  First, preventing testosterone from converting to DHT inhibits the miniaturization of the hair follicles.  Secondly, when the levels of scalp DHT are lowered, the number of hairs in the anagen phase are maintained or increased.  Think of anagen as the active phase of the hair growth cycle.  This is when the cells in the roots of your hair divide rapidly and form new hair.  Elongating the anagen stage gives your hair more time to grow.  

Get More Information On Prescription DHT Blockers

If you’re experiencing androgenetic alopecia and want more information on DHT blockers, contact us.  If, like many, you haven’t yet been to a dermatologist, free phone consultations are available with board-certified dermatologists and hair specialists.  

Formulas are available for men and women and can even be customized based on your specific needs.  We are happy to remove or add ingredients as needed and appropriate.  You can also see before and after photos of our patients.  You can get an idea of what you can realistically expect to see after using Happy Head hair loss solutions that block the DHT causing your alopecia.

Resources:

(01) https://newsroom.clevelandclinic.org/2019/09/04/cleveland-clinic-survey-men-will-do-almost-anything-to-avoid-going-to-the-doctor/

(02) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312176/

(03) https://pubmed.ncbi.nlm.nih.gov/15316165/#:~:text=In%20the%20clinical%20evaluation%20at,the%205%25%20topical%20minoxidil%20group.

(04) http://www.bioline.org.br/pdf?dv09011

(05) https://pubmed.ncbi.nlm.nih.gov/32166351/

(06) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388756/

(07) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769411/